Pairwise cosine similarity for 17 diseases and 28 genera across cohort and KG domains.
Spearman ρ = —
Cosine similarity measures the structural overlap between two disease (or genus) profiles — 1.0 means identical patterns, 0 means no overlap, −1 means opposite. Cohort domain compares the actual abundance shift vectors derived from patient studies. KG domain compares the literature-derived polarity vectors from the knowledge graph. The cross-domain Spearman ρ (—) measures how consistently a pair's cohort ranking matches its KG ranking — limited cross-domain correspondence; the two evidence sources capture distinct biological signals. Hover any cell to see the exact similarity value.