Cross-domain Projection

This heatmap maps 17 multisource diseases (columns) against 684 microbial genera (rows). Cohort signal is the case–control difference in mean abundance states (Low = −1, within range or undetected = 0, High = +1), averaged with equal weight across studies. KG polarity reflects whether the literature knowledge graph supports enrichment (+) or depletion (−) of that genus. Graded alignment is a continuous concordance score combining both signals. Category classifies each cell as Aligned (cohort and KG agree), Opposed (disagree), Exact zero (KG-linked but no cohort signal), or KG-unlinked (no literature evidence). Hover any cell for full provenance.